Synthesizer

DNA RNA Oligo Synthesizers

S-4-LC/S-8-LC

New, smallest DNA/RNA/LNA Synthesizer in the world.

First presentation at

Analytica China, Shanghai

Sept. 15th, 2010

 4 - 8 columns

up to 10 amidite positions

 6 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal)

Cycle time 2,5 - 3 min. for 4 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   25  x  25  x  30

Since 2020 we offer the famous H-2 columns synthesizer:

Low cost - DNA/RNA/LNA Synthesizer

2 columns

up to 12 amidite positions

8 reagent positions

Universal or standard CPG

Variable synthesis scale up to 40 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal) 

Cycle time 2 - 2,5  min. for 2  column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   25  x  40  x  40

H-6

DNA/RNA/LNA Synthesizer

6 columns

up to 12 amidite positions

6 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal) 

Cycle time 2,5 - 3,5  min. for 6 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   25  x  40  x  40

H-8 Standard

DNA/RNA/LNA Synthesizer

8 columns

up to 12 amidite positions

6 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal)

Cycle time 3 - 3,5  min for 8 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   25  x  40  x  40

DNA/RNA Synthesizer H-8 SE

DNA/RNA/LNA Synthesizer

8 columns

up to 20 amidite positions

up to 10 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixedes bas capability)

Automated antisense oligo synthesis (also internal)

Cycle time 3 - 3,5  min for 8 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   35  x  60  x  40

  • 8-columns, DNA/RNA synthesizer
  • 20 amidite positions, different sizes possible

here 10 bottles for 1 or 2 gramm amidites

and  10 bottles  for 4 ml bottles for small value or

very expensive amidites *

*  markers in the sequence stop automatically when the

special amidite is reached: scientist can put the expensive

amidite on the instrument, continue the coupling process and

the instruments stops after reaction and the scientist can remove the 

expensive amidite back to refrigerator.

Because of very compact design nearly no death volume of special 

amidite positions.

  • H-8 SE   special edition
  • here: 24 amidite positions for 1 or 2 gramm bottles
  • here: 10 reagents positions for different bottles*

* all reagents bottle caps of all instruments by customers wishes!

H-8 custom

  • 4-columns, DNA/RNA synthesizer
  • 1heating column
  • 3 standard columns
  • 12 amidite positions, different sizes possible

here: 8 positions of 1gramm or 2gramm bottles

and 4 positions of 4ml bottles for special or expensive amidites

H - 16 standard

DNA/RNA/LNA Synthesizer H-16

16 columns

Standard build:

8 amidite positions 1g/2g bottles

4 amidite positions 4 ml

2 offline amidite positions 4 ml for changing with 1g/2g positions

Customer can request specialty bottle caps

Up to 10 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal) 

Cycle time 5,5 - 6  min for 16 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   35  x  60  x  45

H - 32

DNA/RNA/LNA Synthesizer H-32

32 columns

5 amidite positions 1g/2g/10g bottles

6 reagent positions

Universal or standard CPG

Variable synthesis scale up to 10 µmol

Online trityl monitor for all columns (all trityl collected)

Free programmable synthesis control

New synthesis start on every position while synthesis running

Wobbles (mixed bases capability)

Automated antisense oligo synthesis (also internal) 

Cycle time  7 - 8  min for 32 column synthesis

Low reagent consumption

Design especially for long, highest purity oligos

Very compact design

Dimensions (WxHxD) cm:   35  x  65  x  45

Oligo Purifiers

2 different kinds of RP-purifiers:

the small P-8 purifier for the H-8 synthesizers;

semi manual easy controlled handling

high quality of purification.

the big automated microplate P-96/P192 purifier for H-192,

H-32 synthesizers and H-8 synthesizer production lines.

Before purifying the cleavage step will be made in our cleavage oven.

P - 8

OPC - Purification

  • 8 channels 
  • 5 reagent bottles 
  • 20 minutes purification time for 8 oligos
  • nearly HPLC quality
  • cartridge usable 20 times
  • flexible programming

P - 96/192

Cleavage Oven

Temperature       programmable, up to 85 °C

- Time:                   programmable, 1min – 99 hours

- Shake speed:     programmable, 1 – 5 rotations/sec

- Loading:              56 single vials or one 96-microplate