Synthesizer

Peptide Synthesizers

P11 Automated Peptide Synthesizer

The P11 Peptide Synthesizer is an easy to use and affordable instrument for synthesis of very high quality peptides.

Description

The P11 is the only synthesizer available with both automated reactor heating and UV monitoring. These valuable synthesis tools allow chemists to synthesize longer and more difficult peptides and to gain more synthesis information about those peptides. For example the antimicrobial peptide Gomesin has been successfully synthesized using conventional heating.

Key Features

  • High quality peptides
  • Any scale from 0.005 to 5.0 mmol
  • Easy to use; define own protocols or use the peptide wizard software
  • Performs any Fmoc or t-Boc chemistries
  • PNA synthesis
  • Safe to use, instrument is totally enclosed
  • Fully automatic with no limit to number of amino acids
  • Disposable reactors and amino acid containers
  • Uses commercially available resins and reagents
  • Self diagnostics with fluidic sensors checking reagent delivery, emptying and transfers

High Quality Peptide

  • Inert atmosphere throughout
  • Precise and fast reagent delivery and washing
  • Efficient inversion mixing
  • Bottom filtration from disposable reactors
  • Fresh amino acids in powder
  • Pre-activation vessel
  • Multi-tasking
  • Heated reactors
  • UV monitoring

Chemistry

  • Fmoc or t-Boc
  • PNA synthesis
  • In situ or preactivation
  • Use any coupling reagents; HBTU, HCTU, HATU, TBTU, PyBOP, DIC etc
  • Use any resins; polystyrene or PEG based supports
  • Use any protocols
  • Synthesize any length of peptides

Ease of Use

  • Very easy to use software; import the sequence, fill in quantity and resin specifications then press run
  • Software generated worksheet tells the user what to prepare
  • Free choice of chemistry, present and future
  • Disposable reactors and amino acid containers
  • 60 amino acid containers, no limit to how many can be added
  • Enclosed cabinet for safe bench top use
  • Easy cleave system direct from the disposable reactor
  • Logfile of each synthesis
  • Easy cleavage on the machine or transfer disposable reactor to the P12 Cleavage Device

Dimensions

W – 84cm or 33in D – 59cm or 23in H – 70cm or 28in

Instrument Specification

Scale 0.005 to 5.0 mmol
Chemistry Fmoc or t-Boc
Dissolve dry amino acids or use pre dissolved
Activation method Pre-activation or in situ, user selectable. HBTU, HCTU, COMU, DIC, PyBop etc
Amino acid vessels 60 of 15 mL or 30 of 50 mL arranged in a carousel so no limit
Reaction vessel sizes 10 mL, 40 mL and 125 mL
Reagent/solvent bottles 9, range from 250 mL to 19 litres
2 of 10 litres each
Mixing system Over centre mixing with variable speed and amplitude
Inert atmosphere 100% throughout the system
Fluid measurement Fill loops for calibration free measurement of reagents
Timed delivery for washing solvents
Power Variable range from 240V/50 Hz to 100V/ 60 Hz
Safety CE marked, system enclosed with door interlock
Ventilation Designed for bench top use with extractor attached
Logfile Printable logfile for each synthesis run
Software User friendly interface, pre-written protocols or user defines own
Controller Desktop PC
Temperature Ambient to +90 ºC
Dimensions Width 84 cm (33″), depth 60 cm (23″), height 70 cm (28″)

P12 Cleavage Device

Key Features

  • No need to transfer resin around
  • Inert atmosphere
  • Variable over centre mixing
  • Small footprint to fit into any fume cupboard

P14 Peptide Synthesizer

P14 Peptide Synthesizer is an economical semi-automated instrument for the synthesis of very high quality peptides. This is the smallest and lowest cost peptide synthesizer available.

Key Features

  • High quality peptides
  • Any scale from 0.05 to 5.0 mmoles
  • Easy to use; use existing or define your own protocols
  • Automates the resin washing and deprotection steps of synthesis
  • Performs any Fmoc or t-Boc chemistries
  • Heated reactors
  • PNA synthesis
  • Safe to use, instrument is totally enclosed
  • Disposable reactors
  • Uses commercially available resins and reagents
  • Optional reactor heating

High Quality Peptide

  • Inert atmosphere throughout
  • Precise and fast reagent delivery and washing
  • Efficient inversion mixing & nitrogen bubbling
  • Bottom filtration from disposable reactors

Ease of Use

  • Very easy to use touch screen display
  • Enter the sequence, fill in quantity and resin and press run
  • Software generated worksheet tells the user what to prepare
  • Free choice of chemistry, present and future
  • Disposable reactors
  • Logfile of each synthesis
  • Easy cleave system direct from the disposable reactor

Chemistry

  • Fmoc or t-Boc
  • In situ or pre-activation
  • Coupling reagents HBTU, HCTU, HATU, TBTU, PyBOP, DIC etc
  • PNA synthesis
  • Use any resins; polystyrene or PEG
  • Use any protocols
  • Synthesize any length of peptides

Instrument Specification

Scale 0.05 – 5.0 mmoles
Chemistry Fmoc or t-Boc
Activation method Pre-activation or in-situ, user selectable. HBTU, HCTU, DIC, PyBOP, etc
Reaction vessel sizes 10 mL, 40 mL, 125 mL
Reagent/solvent bottles 3, range from 250 mL to 19 litres
Reactor heating ambient to + 80 degrees C
Mixing system Over centre mixing with variable speed and amplitude
Inert atmosphere 100% throughout the system
Fluid measurement Timed delivery
Power Variable range from 240V/50Hz or 100V/60Hz
Logfile Printable logfile for each synthesis run
Dimensions Width 33 cm (13”), depth 27 cm (11”), height 33 cm (13”) + solvent storage unit

Activo-PLS Parallel Peptide Synthesizer

Description

The PLS Parallel Peptide Synthesizer provides an economic and easy to use parallel synthesis tool to accelerate your chemistry research. Enabling fast lead generation, optimization, process development, combinatorial catalysis etc utilizing a range of PTFE solid phase and glass solution phase reactors.

Can be used for low cost multiple peptide synthesis too!

  • Solution phase chemistry and/or solid phase chemistry
  • Multiple peptide synthesis
  • Scales from 0.5 mL to 50 mL
  • Vortex mixing – variable speed
  • Heating to +150°C, cooling to -80°C
  • Suzuki reactions, amide bond formation, reductive aminations etc etc
  • Parallel washing, product retrieval and cleavage
Activo-PLS Type  Max. Heating  Min.  Cooling  No. of temp. zones  No. of reactors places  Reaction volume range  Max Vial/Reactor diameter  Solid or solution phase capable 
PLS4x6  Y+150°C  N  4  24  0.5mL – 6.0mL  17.1 mm  Both 
PLS4x4  Y+150°C  N  4  16  2.0mL – 14.0mL  27.8 mm  Both 
PLSHybrid  Y+150°C  N  4  20 – 2 rows of 6, 2 rows of 4  0.5mL – 14.0mL  17.1mm and 27.8mm   Both 
PLS50  Y+70°C  N  4  4  30mL in a 50mL reactor  n/a  Solution 
PLS24  Y+150°C  Y -80°C  1  24  0.5mL – 6.0mL  17.1 mm  Both 
PLS6  Y+150°C  Y -80°C  1  6  10.0mL – 50mL  40.5mm  Both 

PLS4x6, PLS4x4 and PLS50 reactor blocks can be interchanged on the same base. 
PLS24 and PLS6 reactor blocks can be interchanged on the same base. 

PLS4x6

  • 4 rows with individual temperature control from room temperature to +150°C
  • Synthesis scale from 0.5 mL to 5 mL

PLS4x4

  • 4 rows with individual temperature control from room temperature to +150°C
  • Synthesis scale up to 20 mL

PLS50

  • 4 rows with individual temperature control from room temperature to +150°C
  • 4 x 50mL round bottom flasks

PLS24 – cool to -80°C in just 20 mins!!

  • Heating and cooling from -80°C to +150°C
  • Dry box prevents any ice formation on cooling
  • Synthesis scale from 0.5 mL to 5 mL

PLS6

  • Heating and cooling from -80°C to +150°C
  • Synthesis scale up to 50 mL

Activo-S44 Automated Organic Synthesizer

The S44 Automated Organic Synthesizer is an easy to use and affordable instrument for automated synthesis of organic chemistry.

Key Features

  • High quality compounds
  • Any scale from 0.05 mmol to 2.0 mmoles
  • Easy to use; use prewritten or define own protocols
  • Performs wide range of solid phase chemistries
  • Reactor cooling to -30°C and heating to +80°C
  • Safe to use, instrument is totally enclosed
  • Fully automatic with no limit to number of building blocks
  • Disposable 10 mL and 50 mL reactors
  • Uses commercially available resins and reagents

Ease of Use

  • Very easy to use software; import the sequence, fill in quantity and resin and press run
  • Software generated worksheet tells the user what to prepare
  • Free choice of chemistry, present and future
  • Unattended operation for full length of the synthesis
  • Disposable reactors and building block containers
  • 60 building block containers, no limit to how many can be added
  • Enclosed cabinet for safe bench top use
  • Easy cleave system direct from the disposable reactor

High Quality Compound

  • Inert atmosphere throughout
  • Reaction temperature monitoring and logging
  • Precise and fast reagent delivery and washing
  • Efficient inversion mixing
  • Bottom filtration from disposable reactors
  • Fresh building blocks in powder
  • Pre-activation vessel
  • Multi-tasking

Dimensions

Width – 84 cm or 33 inches, depth – 60 cm or 23 inches, height – 70 cm or 28 inches